Scientists hoping to mimic the life-extending qualities produced by a chemical found in red wine and dark chocolate say they have solved one of the mysteries about how this compound works to combat the effects of obesity, diabetes, certain cancers and a host of other maladies.
The findings, published in Friday's edition of the journal Science, could lay the foundation for a variety of drugs that act like concentrated amounts of resveratrol, the compound that has inspired a $30-million-a-year supplement business. Pharmaceutical giants have invested millions of dollars in the quest to improve on the compound that helps rev up the body's cellular defenses against disease and aging.
A major branch of anti-aging research centres on the effects of calorie restriction, which can send cells into a crisis mode that prompts them to repair damage and stave off hazardous changes in cellular activity. Resveratrol, found in such foods as grapes, peanuts, cocoa and berries, provokes similar reactions.
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